Endocrine Abstracts

Objectives: Considerable evidence shows that increased serum calcium levels are associated with metabolic disorders, cardiovascular disease and increased mortality. This study investigated whether serum calcium, within a normal range, is significantly associated with serum fibrinogen and homocysteine, markers of increased cardiovascular disease risk in non-diabetic Korean subjects.Methods: A cross-sectional analysis was performed on 1096 subjects (mean a...

CDC73 (also known as HRPT2) encodes parafibromin and is known to be the causative gene of hyperparathyroidism-jaw tumor (HPT-JT) syndrome. There is no known ubiquitination of parafibromin, and the deubiquitinating enzyme (DUB) for parafibromin has not been identified to date. Full-length DUB cDNAs encoding 58 family members of ubiquitin specific proteases (USPs) were subcloned. The DUB cDNA was used to identify parafibromin interacting by yeast two-hybrid screening. W...

Objective: Obesity is a well-known risk factor for type 2 diabetes, but few data exist on the association between weight changes and future diabetes risk in non-obese subjects. This study aimed to investigate the effect of weight changes on the incidence of type 2 diabetes in Korea, using prospective nationwide data.Research design and methods: A total of 51 405 non-diabetic subjects were included who had undergone health examinations in 2002 and complet...